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Infiammazione cronica silente: la causa sottostante all’anemia cronica dell’anziano

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Alcohol and dementia risk: new evidences suggest that any amount may increase it

Background

Dementia is a major global health challenge, with over 50 million people affected worldwide and a number that is expected to grow in the coming decades. Dementia, a syndrome that affects memory, thinking, behavior, and the ability to perform daily activities, is closely associated with aging. However, modifiable risk factors, such as alcohol consumption, can significantly influence the risk of developing this disease. Although it has long been known that alcohol abuse increases the risk of cognitive impairment and dementia, new research suggests that even moderate alcohol consumption can have negative effects on the brain and increase the risk of dementia. This article will explore the results of these recent studies, discussing the link between alcohol and dementia, the underlying mechanisms, and the clinical implications of these findings for public health.

The effects of alcohol on the brain

Alcohol consumption, especially in excess, has well-documented effects on the central nervous system. Alcohol acts as a nervous system depressant and interferes with communication between brain cells, negatively affecting short- and long-term cognitive function. Alcohol toxicity, combined with accumulated oxidative damage and inflammation, can damage key brain structures involved in memory and thinking, such as the hippocampus and prefrontal cortex. The most serious effects of chronic alcohol consumption are seen in those with alcoholism. Studies show that prolonged heavy alcohol consumption can lead to a reduction in brain volume, changes in white matter, and permanent neuronal damage. Alcohol can also impair the absorption of B vitamins, such as thiamine, which is essential for neuronal health. Thiamine deficiency is closely linked to Wernicke-Korsakoff syndrome, a form of dementia caused by severe long-term memory impairment and confabulation.

Mechanisms of alcohol-induced brain damage

But why does alcohol appear to have such a significant impact on brain health, even at relatively low doses? Researchers are studying several mechanisms by which alcohol can damage brain structures and lead to an increased risk of dementia. Alcohol consumption can induce systemic inflammation and oxidative stress, both of which have been implicated in the pathogenesis of dementia. Oxidative stress causes damage to neurons through the excessive production of free radicals, unstable molecules that can damage brain cells. Chronic inflammation, on the other hand, contributes to synaptic dysfunction and neuronal loss, which are common features of neurodegenerative diseases such as Alzheimer’s.

Alcohol interferes with neuroplasticity, the brain’s ability to adapt and form new synaptic connections. Neuroplasticity is essential for learning and memory, and any impairment of this process can accelerate cognitive decline. Alcohol can also affect neurogenesis, or the brain’s ability to create new neurons, especially in the hippocampus, a key region for memory. Some studies suggest that alcohol may contribute to the buildup of toxic proteins in the brain, such as beta-amyloid and tau, both of which are hallmark pathological markers of Alzheimer’s disease. Alcohol may facilitate the buildup of these proteins by disrupting the brain’s “cleaning” mechanisms, known as the lymphatic system.

Effects of moderate drinking

Until recently, it was thought that moderate alcohol consumption could have protective effects against certain chronic diseases, including cardiovascular disease. However, recent studies are challenging this idea, especially when it comes to the brain. New evidence suggests that even moderate amounts of alcohol may negatively impact brain health, accelerating cognitive decline and increasing the risk of developing dementia. A new study has raised significant concerns about alcohol consumption and the risk of dementia. The study, which included a large sample of adults, found an increased risk of developing dementia in individuals who consumed alcohol, regardless of the amount. This suggests that there is no “safe dose” of alcohol when it comes to protecting against dementia, and that even moderate or occasional drinking could be harmful to cognitive health.

The study followed more than 20,000 people over several years, tracking their alcohol consumption and cognitive function. The researchers found that, compared to teetotalers, even those who drank moderate amounts of alcohol (defined as one to two drinks per day) had a significantly increased risk of developing dementia. These findings contradict previous ideas that moderate alcohol consumption, particularly red wine, has protective effects on the brain. These findings raise important questions for alcohol consumption guidelines. Many countries recommend moderate alcohol consumption as part of a balanced diet, but these new findings could lead to a review of those recommendations. The knowledge that even small amounts of alcohol can increase the risk of dementia highlights the importance of educating the public about the long-term effects of alcohol consumption on brain health.

Prevention and clinical implications

The new findings on the link between alcohol and dementia have important implications for prevention and public health. These findings suggest that reducing or eliminating alcohol consumption may be an effective strategy to reduce the risk of dementia, especially in older people and those with pre-existing risk factors. Current alcohol guidelines vary by country, but many recommend moderate consumption. However, in light of these new findings, these recommendations may need to be revised to account for risk even with low or moderate consumption. Educating the public about the cognitive risks of alcohol, regardless of the amount consumed, is essential. New evidence suggests that any amount of alcohol, even moderate, may increase the risk of dementia. Although moderate alcohol consumption was once thought to be safe or even beneficial for health, it is increasingly clear that there is no “safe” amount of alcohol when it comes to brain health.

  • Edited by Dr. Gianfrancesco Cormaci, PhD, specialist in Clinical Biochemistry.

Scientific references

Livingston G et al. Lancet. 2020; 396(10248):413-446.

Schwarzinger M et al. Lancet Pub Health 2018; 3(12):e514.

Kivipelto M et al. Lancet Neurology. 2018; 17(3):270-280.

Rehm J, Roerecke M. Addiction Biol. 2017; 22(2):348-57.

Topiwala A et al. British Medical J. 2017; 357:j2353.

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Dott. Gianfrancesco Cormaci
Dott. Gianfrancesco Cormaci
Laurea in Medicina e Chirurgia nel 1998; specialista in Biochimica Clinica dal 2002; dottorato in Neurobiologia nel 2006; Ex-ricercatore, ha trascorso 5 anni negli USA (2004-2008) alle dipendenze dell' NIH/NIDA e poi della Johns Hopkins University. Guardia medica presso la casa di Cura Sant'Agata a Catania. Medico penitenziario presso CC.SR. Cavadonna (SR) Si occupa di Medicina Preventiva personalizzata e intolleranze alimentari. Detentore di un brevetto per la fabbricazione di sfarinati gluten-free a partire da regolare farina di grano. Responsabile della sezione R&D della CoFood s.r.l. per la ricerca e sviluppo di nuovi prodotti alimentari, inclusi quelli a fini medici speciali.

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