Tag:

cancer cells

Brain cancer “going APE”: here is its way to resist TMZ and leave DNA repair BEReft with options

In spite of intensive research, glioblastoma remains one of the most lethal types of brain cancer. Despite there are several available medications, temozolomide (TMZ) is...

AP-1: a keymaster FOStering the JUNction among several tissues by wERKing on the cellular MAPk

AP-1: ID and biological functions AP-1 (Activator Protein-1) is a transcription factor that plays a key role in regulating gene expression involved in a wide...

Nutrizione nei tumori: il delicato gioco metabolico di proteine, enzimi e metaboliti che coordina tutte le risposte cellulari

Background Dieta e nutrizione svolgono un ruolo fondamentale nella salute umana, con quantità, composizione e qualità della dieta, nonché orari dei pasti, fattori determinanti per...

Iron eating “stems off”: how to solve an AMLetic doubt to kill dormant leukemic progenitors

Acute myeloid leukemia (AML) is the most common cancer of the blood and bone marrow in adults. Caused by an increase in immature cells...

There is no “playing dices” where it comes with cancer: genetics and immunity always get in the way

A Stanford Medicine study of thousands of breast cancers has found that the gene sequences we inherit at conception are powerful predictors of the...

DNA-bound lactate? True enough, but it’s not about tiredness: rather it’s cellular intentions and mood shifts

Lactic acid is a well-known metabolite, found in almost all cell types and is very abundant in proliferating tumor cells due to the Warburg...

Cancer kills by lactate: how cellular junk becomes a signal to acquire more fuel and waste the body to death

Cachexia is a complex metabolic syndrome associated with rapid loss of body weight, mainly loss of fat and lean muscle. Patients with cancer cachexia...

LifeTracking of cellular therapy: doom receptors show their “inner spark” to lead cancer cells to a FASt death

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein)...